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In hepatocellular carcinoma, CD133 enhances stemness by stabilizing EGFR-AKT signaling, as the absence of EGFR causes CD133 + cells to lose their stemness properties

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Kumar and Bachhawat hypothesized that this leads to the combination of cytosolic cysteine and glutathione depletion, which activates the ATP-depleting futile 5-oxoproline cycle